- βSimplified monitoring: Just two CGM measures (TIR and time below 70 mg/dL) can predict over 81% of all other glucose outcomes
- βAchieving a GMI under 7% on the 780G system naturally brings most other CGM targets in line with clinical guidelines
- βFindings apply to both adults and children/teens, making this widely relevant for type 1 diabetes management
| Journal | Diabetes, obesity & metabolism |
| Year | 2024 |
| PMID | 39323365 |
What This Study Is About
Researchers looked at how different continuous glucose monitor (CGM) measurements relate to each other in people with type 1 diabetes using the Medtronic 780G automated insulin delivery (AID) system. Their goal was to find out whether hitting one target automatically helps meet others.
Key Terms Explained
- GMI (Glucose Management Indicator): An estimate of your average blood sugar, similar to HbA1c, calculated from CGM data.
- Time in Range (TIR): The percentage of time your glucose stays between 70β180 mg/dL.
- Time in Tight Range (TITR): Time spent between 70β140 mg/dL β a stricter target.
- Time Above Range (TA180/TA250): Time spent above 180 or 250 mg/dL (high blood sugar).
- Time Below Range (TB70/TB54): Time spent below 70 or 54 mg/dL (low blood sugar/hypoglycaemia).
What They Found
The study used real-world data from over 41,000 adults and nearly 14,500 children and teens using the 780G system. Key findings include:
- To achieve a GMI below 6.5%, users needed: TIR above 81%, TITR above 58%, time above 180 mg/dL below 15%, and time above 250 mg/dL below 1.9%.
- These high-sugar targets were all very closely linked β if you meet one, you're likely meeting the others.
- However, low blood sugar (hypoglycaemia) targets were NOT closely tied to GMI or TIR. This means you could have good average glucose control but still experience too many lows.
- Researchers found that just two measures β GMI (or TIR) and time below 70 mg/dL β can predict over 81% of all other CGM outcomes.
Why This Matters for Patients
If you use an AID system like the 780G, your diabetes care team may be able to simplify your glucose targets. Instead of tracking many different CGM numbers, focusing on TIR and low blood sugar time may give a complete picture of your glucose health. Importantly, keeping lows in check needs to be monitored separately β good average control doesn't automatically mean you're safe from hypoglycaemia.
Who Was Studied
Over 56,000 real-world users of the Medtronic MiniMed 780G system were included β both adults (over 15 years) and younger users (15 and under), with similar results found in both groups.